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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AFF2 All Species: 7.27
Human Site: S367 Identified Species: 22.86
UniProt: P51816 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P51816 NP_002016.2 1311 144771 S367 I L R E M T H S W P T P L T S
Chimpanzee Pan troglodytes Q7YQM2 1272 140491 L363 I L R E S Q H L T P G F T L Q
Rhesus Macaque Macaca mulatta XP_001088220 1311 144821 S367 I L R E M T H S W P T P L T S
Dog Lupus familis XP_549313 1547 169935 S549 I L G K M K R S N I L P G K I
Cat Felis silvestris
Mouse Mus musculus O55112 1272 140163 L367 I L R E S Q H L T P G F T L Q
Rat Rattus norvegicus XP_219832 1355 148400 L406 I L R S M T H L E P A S L T D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507403 1221 131271 H334 L T N K D S Q H V S T G H L I
Chicken Gallus gallus XP_001233772 1353 145477 T368 K H G S L R A T L G D S V N R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.4 98.1 71.2 N.A. 86.3 84.3 N.A. 32.6 23.4 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 96.7 99 75.1 N.A. 90.5 88.7 N.A. 48.9 40.7 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 40 100 33.3 N.A. 40 60 N.A. 6.6 0 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 100 40 N.A. 40 60 N.A. 26.6 20 N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 13 0 0 0 13 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 13 0 0 0 0 0 13 0 0 0 13 % D
% Glu: 0 0 0 50 0 0 0 0 13 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 % F
% Gly: 0 0 25 0 0 0 0 0 0 13 25 13 13 0 0 % G
% His: 0 13 0 0 0 0 63 13 0 0 0 0 13 0 0 % H
% Ile: 75 0 0 0 0 0 0 0 0 13 0 0 0 0 25 % I
% Lys: 13 0 0 25 0 13 0 0 0 0 0 0 0 13 0 % K
% Leu: 13 75 0 0 13 0 0 38 13 0 13 0 38 38 0 % L
% Met: 0 0 0 0 50 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 13 0 0 0 0 0 13 0 0 0 0 13 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 63 0 38 0 0 0 % P
% Gln: 0 0 0 0 0 25 13 0 0 0 0 0 0 0 25 % Q
% Arg: 0 0 63 0 0 13 13 0 0 0 0 0 0 0 13 % R
% Ser: 0 0 0 25 25 13 0 38 0 13 0 25 0 0 25 % S
% Thr: 0 13 0 0 0 38 0 13 25 0 38 0 25 38 0 % T
% Val: 0 0 0 0 0 0 0 0 13 0 0 0 13 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _